Rohr suggested pre-match that he was going to make two or three changes to the team that lost 1-0 in the first leg three days ago.
One of those changes sees Maduka Okoye replace Francis Uzoho in between the pipes.
It will be a back three of Leon Balogun, William Troost-Ekong and Chidozie Awaziem in front of the Sparta Rotterdam goalkeeper.
Brentford midfielder Frank Onyeka makes his second consecutive start for the Super Eagles for the first time in his career and joining him in the middle of the park is Joe Aribo, while Kelechi Iheanacho has been handed playmaking duties.
Victor Osimhen will spear-head the attack, and will be supported by captain Ahmed Musa.
Nigeria starting line-up vs CAR : Okoye; Awaziem, Balogun, Troost-Ekong; Simon, Aribo, Onyeka, Collins, Iheanacho; Osimhen, Musa.
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